The in vitro effect of new muramyl peptide derivatives on cytotoxic activity of NK (Natural Killer) cells from hamsters bearing AB Bomirski Melanoma |
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Authors: | Danuta Sosnowska Andrzej Mysliwski Krystyna Dzierzbicka Aleksander M Kolodziejczyk |
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Institution: | (1) Department of Histology and Immunology, Medical University of Gdansk, Debinki 1, 80-210 Gdansk, Poland;(2) Department of Organic Chemistry, Technical University of Gdansk, G. Narutowicza 11/12, 80-952 Gdansk, Poland |
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Abstract: | The modulation of NK activity by muramyl dipeptides derivatives against Ab (amelanotic) Bomirski melanoma and human erythroleukemia
K562 cells was studied in vitro. The stimulatory effect was observed for 3 of 7 muramyl dipeptides: MDP(L-Ala)C921, MDPC857
and L18-MDP(Ala) in relation to cytotoxic activity of NK cells obtained from peripheral blood and spleen of healthy and Ab
Bomirski melanoma bearing hamsters. An increased of cytotoxic activity NK cells isolated from animals before and during the
transplantable phase of the tumor against K562 was found. A similar stimulation was received for NK cells obtained from animals
against their own melanoma cells. The most significant influence of examined MDP derivatives on the cytotoxic activity of
NK cells were obtained from animals between 10 to 12 days of tumor growth. The extent of the modulation of cytotoxic activity
of NK cells was dependent on its initial value both in healthy control and Ab Bomirski melanoma bearing hamsters. If natural
cytotoxic activity was high the stimulatory effect of the examined MDP derivatives was only slightly expressed. |
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Keywords: | hamster melanoma muramyl peptide NK cells |
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