Studies on solvatochromic properties of aminophenylstyryl-quinolinum dye, LDS 798, and its application in studying submicron lipid based structure期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Studies on solvatochromic properties of aminophenylstyryl-quinolinum dye, LDS 798, and its application in studying submicron lipid based structure

Authors:	Sarkar Pabak Luchowski Rafal Raut Sangram Sabnis Nirupama Remaley Alan Lacko Andras G Thamake Sanjay Gryczynski Zygmunt Gryczynski Ignacy

Institution:	^a Center for Commercialization of Fluorescence Technologies, University of North Texas Health Science Center, Fort Worth, TX 76107, United States ^b Department of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, United States ^c Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, United States ^d Department of Laboratory Medicine, National Institute of Health, Bethesda, MD, United States ^e Department of Cell biology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, United States

Abstract:	The styryl group of dyes has been used in cellular studies for over 20 years because of their solvatochromic and/or electrochromic properties. Here we report characterization of solubility and solvatochromic properties of a near infra-red styryl dye, styryl 11 or LDS 798. We have extended our studies to small unilamellar vesicles and lipid based nanoparticles and found that solvatochromic properties of this dye used in tandem with fluorescence correlation spectroscopy can be used to efficiently determine the diffusion coefficient and hence the size of the submicron lipid based particles. This technique has the potential to provide essential information about liposomal and vesicular structures and their movement in vitro and in situ.

Keywords:	Aminostyryl quinolinum dye Fluorescence correlation Spectroscopy Solvatochromism
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