老年大鼠学习记忆减退的神经基础

对由Ｍｏｒｒｉｓ水迷宫分得的青年、老年记忆正常和记忆减退鼠的脑组织分别进行突触、ＡＣｈＥ纤维、突触素、小白蛋白神经元以及突触体钙离子浓度、膜流动性的定量分析。结果表明老年记忆减退鼠新皮质、海马结构突触素含量、突触、胆碱能纤维、小白蛋白阳性神经元密度及突触体膜流动笥较老年记忆正常和青年鼠明显降低。老年记忆正常鼠与青年鼠各项均无显著差异。本研究提示各研究指标的异常与老年学习记忆减退密切相关。

The Neural Basis of Learning and Memory Declines in Aged Rats

The synapses,AChE fibers,synaptophysin(SYP),parvalbumin(PV)-containting neurons,synaptosomal Ca2+ concentration and membrane fluidity were studied quantitatively in the brain tissues of young and aged memory-nonimpaired and aged memory- impaired rats according to their memory abilities in the Morris water maze.The results indicated that statistically significant decreases were found in SYP content,the density of synapses,AChE fibers,PV positive neurons and synaptosomal membrane fluidity while an increase was found in Ca2+]i of neocortex and hippocampal formation in the aged memoryimpaired rats as compared with the young and aged memory- nonimpaired rats.But there were no significant differences of these indexes between the young rats and the aged memory-nonimpaired ones.The study suggested that the abnormality of these indexes was closely correlated with the decline of learning and memory in aged rats.