| 衰老与血管钙化 |
| |
| 引用本文： | 陈瑶,鱼艳荣,齐永芬.衰老与血管钙化[J].生理科学进展,2019(2):81-87. |
| |
| 作者姓名： | 陈瑶 鱼艳荣 齐永芬 |
| |
| 作者单位： | 北京大学基础医学院生物活性小分子研究室;北京大学基础医学院病原生物学系;北京大学医学部分子心血管学教育部重点实验室 |
| |
| 基金项目： | 国家自然科学基金(81670434和91339203)资助课题 |
| |
| 摘 要： | 血管钙化是指体内钙磷在血管壁的异常沉积,是一个主动的、高度可调节的、类似于骨形成的生物学过程。血管钙化是引起心血管疾病发病率、病死率升高的重要原因,也是危害中老年人身体健康的广泛存在的病理现象。近年研究表明,衰老与血管钙化存在密切关系,衰老可以通过诱导血管平滑肌细胞成骨样转化、内皮细胞释放囊泡、细胞外基质重塑、DNA损伤、炎症反应、磷代谢失衡以及抗衰老因子如Klotho和Sirtuin 1的表达减少而促进血管钙化。
|
| 关 键 词： | 血管钙化 衰老 血管平滑肌细胞 |
Aging and Vascular Calcification |
| |
| CHEN Yao,YU Yan-Rong,QI Yong-Fen.Aging and Vascular Calcification[J].Progress in Physiological Sciences,2019(2):81-87. |
| |
| Authors: | CHEN Yao YU Yan-Rong QI Yong-Fen |
| |
| Institution: | (Laboratory of Cardiovascular Bioactive Molecule,School of Basic Medical Sciences,Peking University, Beijing 100191,China;Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Peking University Health Science Center, Beijing 100191,China;Department of Pathogen Biology,School of Basic Medical Sciences,Peking University, Beijing 100191,China) |
| |
| Abstract: | CHEN Yao;YU Yan-Rong;QI Yong-Fen(Laboratory of Cardiovascular Bioactive Molecule,School of Basic Medical Sciences,Peking University, Beijing 100191,China;Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Peking University Health Science Center, Beijing 100191,China;Department of Pathogen Biology,School of Basic Medical Sciences,Peking University, Beijing 100191,China) |
| |
| Keywords: | vascular calcification aging vascular smooth muscle cell |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
