| 癌症痛的神经生物学机制研究进展 |
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| 作者姓名： | Zhang Y Han JS Wang Y |
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| 作者单位： | 北京大学神经科学研究所,神经科学教育部重点实验室,北京,100083 |
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| 基金项目： | 国家重点基础研究计划“脑功能和脑重大疾病的基础研究(G19990 5 4 0 0 0 )”，国家自然科学基金委重点项目(30 330 0 2 6 )资助课题 |
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| 摘 要： | 癌症痛是影响癌症病人生活质量的一个严重问题 ,但长期以来由于缺乏合适的动物模型 ,对其神经机制的研究甚少。近年出现的小鼠股骨、跟骨、肱骨和大鼠胫骨癌症痛模型 ,极大地推动了癌症痛的基础研究。初步研究表明 ,癌症痛有其独特的神经化学机制 ,骨质破坏、外周敏化、中枢敏化及神经侵蚀都参与了癌症痛的产生。本文综述了癌症痛动物模型、癌症痛的产生机制及其药物治疗等方面的研究进展。
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| 关 键 词： | 癌性骨痛 动物模型 神经机制 药物治疗 |
Progress in the basic research on neurobiological mechanisms of cancer pain |
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| Zhang Y,Han JS,Wang Y.Progress in the basic research on neurobiological mechanisms of cancer pain[J].Progress in Physiological Sciences,2004,35(3):224-228. |
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| Authors: | Zhang Ying Han Ji-Sheng Wang Yun |
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| Institution: | Neuroscience Research Institute, Peking University, Beijing. |
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| Abstract: | Pain shows the most disruptive influence on the quality of the life of cancer patients. However, the basic neurobiology of cancer pain is poorly understood, as no appropriate animal model of cancer pain is available. New insights into these mechanisms are now arising from femur, calcaneus, humerus model of cancer pain in murine and tibia model in rats. Cancer pain has its unique mechanisms such as osteolysis, peripheral sensitization, central sensitization and nerve entrapping, which are all involved in the development and maintenance of cancer pain. Here we summarized the study progress of cancer pain animal models, neurochemical mechanisms and drugs for treatment of cancer pain from recent literatures. |
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| Keywords: | Cancer pain Animal model Neural mechanism Drug therapy |
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