| LPS介导细胞激活的信号转导：从CD14到p38MAPK通路的研究 |
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| 作者姓名： | Jiang Y Ulevitch RJ |
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| 作者单位： | [1]第一军医大学全军休克微循环重点实验室 [2]美国Scripps研究院免疫学系 |
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| 摘 要： | 近年来对脂多糖（ＬＰＳ）介导细胞激活的信号转导过程已取得实质性进展，ＬＰＳ与血浆ＬＰＳ结合蛋白（ＬＢＰ）结合被运输到单核巨噬细胞表面，与ｍＣＤ１４受体结合起起细胞激活。ＭＡＰＫ参与了ＬＰＳ激活细胞产生肿瘤坏死因子（ＴＮＦ）等活性物质的细胞内信号转导过程。ｐ３８ＭＡＰＫ对ＴＮＦ－α等细胞因子具有重要的调节作用。对ＬＰＳ激活细胞的信号转导研究呆能为治疗内毒素休克提供新的理论和思路。
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| 关 键 词： | 中毒性休克 脂多糖 信号转导 CD14 MAPK |
The signal transduction of cell activation by LPS: the studies from CD14 to p38 MAPK |
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| Jiang Y,Ulevitch RJ.The signal transduction of cell activation by LPS: the studies from CD14 to p38 MAPK[J].Progress in Physiological Sciences,1999,30(1):29-34. |
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| Authors: | Jiang Y Ulevitch R J |
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| Institution: | Key Laboratory for Shock and Microcirculation of PLA, First Military Medical University, Guangzhou 510515. |
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| Abstract: | Recently there have been some substantial progresses in signal transduction of cell activation by lipopolysaccharide (LPS). After binding with LBP in the plasma, LPS is transported to the cell membrane surface of monocytes, then binds with membrane CD14 to induce cell activation. Mitogen-activated protein kinases (MAPKs) take part in the signal transduction of LPS stimulated cell activation to produce bioactive substances including tumor necrosis factor. p38 MAPK is an important regulator for TNF-alpha expression. It is possible to provide new theory and idea for the treatment of septic shock from the studies of signal transduction of cell activation by LPS. |
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| Keywords: | Lipopolysaccharide Signal transduction Mitogen activated protein kinase CD14 |
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