| 五味子酚等三种抗氧化剂对氧化应激损伤中枢神经细胞的保护作用及其作用机 |
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| 作者姓名： | Li L |
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| 作者单位： | 中国医学科学院,中国协和医科大学药物研究所 |
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| 摘 要： | 氧化应有激（ｏｘｉｄａｔｉｖｅ ｓｔｒｅｓｓ）在中区神经系统退行性疾病，如帕金森氏病、老年性痴呆和多发性硬化等的发病机制中起重要作用。这些疾病严重影响着老年人的生活质量，因此寻找有效的抗氧化剂用于防治中枢神经系统退行性疾病的发生和发展是一个十分重要的迫切的问题。本文研究了五味子酚（Ｓａｌ）、丹酚酸Ａ（ＳａｌＡ）和ＳＹ－Ｌ三种化合物对氧化应激损伤中枢神经的保护作用及其作用机理。Ｓａｌ和ＳａｌＡ分别为
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| 关 键 词： | 氧化应激 抗氧化剂 五味子酚 脑损伤 |
Protective effects of schisanhenol,salvianolic acid A and SY-L on oxidative stress induced injuries of cerebral cells and their mechanisms |
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| Li L.Protective effects of schisanhenol,salvianolic acid A and SY-L on oxidative stress induced injuries of cerebral cells and their mechanisms[J].Progress in Physiological Sciences,1998,29(1):35-38. |
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| Authors: | Li L |
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| Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050. |
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| Abstract: | Oxidative stress may play an important role in neuronal degenerative diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. These disorders make the elderly not being able to live normally and move freely. So it is necessary to find effective antioxidants to prevent or cure the aged persons from diseases related to neuronal degeneration. Schisanhenol (Sal) and salvianolic acid A (Sal A) are known antioxidants which were isolated from Chinese herbs respectively. SY-L is a totally synthetic new compound. The results showed that Sal, Sal A and SY-L significantly protect cerebral cells from the injuries induced by oxidative stress. |
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