老年学习记忆减退的神经行为学基础

用改良Ｍｏｒｒｉｓ水迷宫将老年大鼠分为老年学习记忆减退组和老年学习记忆正常组，并与青年组对照，检测其空间参考记忆和空间工作记忆，并对海马结构内胶质纤维酸性蛋白（ＧＦＡＰ）阳性胶质细胞和ＧＡＢＡ能中间神经元在光镜和电镜水平进行定量分析。结果显示老年学习记忆减退大鼠的空间参考记忆能力明显下降，并且其行为模式发生了改变，空间工作记忆改变不明显；齿状回分子层的病理改变非常明显，表现为ＧＡＢＡ能神经元丢失和

The neuroethological basis of learning and memory decline in aged rats

The spatial reference and working memory abilities, GFAP positive astrocytes and GABAergic interneurons were studied quantitatively in young, aged memory unimpaired and aged memory impaired rats according to their learning and memory abilities in the Morris water maze. The results showed that the prominent behavioural features of the aged memory impaired rat were a change in the searching pattern, a decrease in the spatial reference memory, no significant decrease in the spatial working memory was observed.The decrease of GABAergic neurons, and the increase of GFAP positive astrocytes in the dentate gyrus of the aged memory impaired rat were more obvious than the other two groups. The main abnormalities of morphologic indexes were closely correlated with the decline of learning and memory in the aged rat.