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铜蓝蛋白与脑铁代谢
引用本文:常彦忠,钱忠明.铜蓝蛋白与脑铁代谢[J].生理科学进展,2002,33(2):101-105.
作者姓名:常彦忠  钱忠明
作者单位:香港理工大学应用生物及化学科技系,香港
摘    要:铜蓝蛋白(Cerulopasmin,CP)是人体重要的亚铁氧化酶。它的主要作用是催化二阶铁成为三阶铁,从而促进铁与转铁蛋白结合。由于它的

关 键 词:铜蓝蛋白  脑铁代谢  无铜蓝蛋白血症  细胞铁摄取  细胞铁释放

Ceruloplasmin and Brain Iron Metabolism
CHANG Yan-Zhong,QIAN Zhong-Ming.Ceruloplasmin and Brain Iron Metabolism[J].Progress in Physiological Sciences,2002,33(2):101-105.
Authors:CHANG Yan-Zhong  QIAN Zhong-Ming
Abstract:Ceruloplasmin (CP) is a critical ferroxidase in humans. During the past three decades, it was widely believed that this protein has a role in iron release from cells, including brain cells. However, recent studies show that this view might not be completely right or accurate. New findings imply that CP might play a role both in iron release and iron uptake in brain cells. The involvement of CP in iron uptake might be a more important physiological role of CP than its role in iron release. In this short article we discussed recent advances in this aspect as well as the relationship between disregulation of CP and neurodegeneration.
Keywords:Ceruloplasmin  Brain iron metabolism  Aceruloplasminemia  Cell iron release  Cell iron uptake
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