心肌细胞肥大的信号转导通路

心肌肥厚是肥大刺激诱导核内基因异常表达的结果，细胞内信号转导通路是肥大刺激与核内基因转录活化的偶联环节。然而，淡同刺激诱导的心肌肥大可能具有不同的“分子表型”，这主要取决于它们启动的信号转导通路。对心肌肥大信号转导通路的深入认识，不仅胡助于阐明心肌肥厚的细胞分子机制，而且可为药物干预防治心肌肥厚提供新思路。

Signal transduction pathways in cardiac myocyte hypertrophy

Cardiac hypertrophy is the consequence of hypertrophic stimulus-induced changes in gene expression, which is linked by intracellular signal transduction. It is likely, however, that there are "molecular phenotypic" differences underlying cardiac hypertrophy triggered by different stimuli, which is caused by the different signal pathways that they initiated. Studying on the signal pathways in cardiac myocyte hypertrophy contributed to elucidate the cellular and molecular mechanisms of cardiac hypertrophy and might find some new strategies for the prevention of cardiac hypertrophy.