涡虫在研究药物成瘾机制中的应用

药物成瘾危害人类健康并带来经济和社会问题,而滥用药物所造成的身体损害、身体依赖和戒断综合征的治疗等问题的解决仍存在困难.涡虫具有原始的中枢神经系统,其神经递质系统与哺乳类相似,具有易观察可量化的戒断反应,具有易饲养、低成本、无伦理问题等优于哺乳类实验动物的特点,因而迅速成为新的神经药理学在体动物实验模型.本文对涡虫的优点及其在药物成瘾机制等方面的研究进展进行综述,为药物成瘾机制及其治疗的研究提供新的思路.

Investigations of drug addiction mechanism in planarians

Drug abuse harms people's health and lead to a series of economic, social and political problems. However, the problems of physical damage, physical dependence and withdrawal syndrome caused by drug abuse still exist. Planarians have been a new animal experimental model in vivo for neuropharmacology, because they possess a primitive central nervous system and neurotransmitter systems similarly to mammalians. In addition, they have the advantage of convenience and low cost and no ethics problems compared with mammalian models. The advantages of planarian as experimental model in vivo and the progress of the investigations of drug addiction mechanism in planarians are summarized, and the trends in this field are discussed in this review.