| 神经营养因子与神经干细胞 |
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| 作者姓名： | Sun Y Shi J Lu PH |
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| 作者单位： | 上海第二医科大学神经生物学实验室,上海,200025 |
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| 基金项目： | 上海市科学技术发展基金资助课题(OOJC 14021) |
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| 摘 要： | 生长因子在神经干细胞的增殖,分化和存活过程中有重要作用。神经营养因子是其中的一类,它包括神经生长因子（NGF）家族,胶质源性神经营养因子（GDNF）家族和其它神经营养因子。NGF家族包括NGF,BDNF,NT－3,NT－4／5和NT－6。这一家族可促进epidermic growth facter(EGF)反应 海马及前脑室管膜下区神经干细胞的存活和分化。GDNF家族包括GDNF,NTN,PSP和ART。GDNF家族促神经发育的作用主要在外周,它促进肠神经嵴前体细胞的存活和增殖,且对外周感觉神经的发育至关重要。其它生长因子如bFGF和EGF,它们能促进神经干细胞增殖和存活;CNTF和LIF等在神经干细胞的分化中也有重要作用。
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| 关 键 词： | 神经营养因子 神经干细胞 神经发育 |
Neurotrophic factors and neural stem cells |
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| Sun Y,Shi J,Lu PH.Neurotrophic factors and neural stem cells[J].Progress in Physiological Sciences,2002,33(4):313-316. |
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| Authors: | Sun Yong Shi Jian Lu Pei-Hua |
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| Institution: | Department of Neurobiology, Shanghai Second Medical University, Shanghai 200025. |
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| Abstract: | Neurotrophic factors includes nerve growth factors (NGF) family, glial cell line-derived neu-rotrophic factors (GDNF) family and other neurotrophic factors. NGF, BDNF, NT-3 , NT-4/5 and NT-6 constitute NGF family (the neurotrophins) , which may enhance both survival and differentiation of neurons from the EGF-responsive hippocampal and the subventricular zone neural stem cells. GDNF family includes GDNF, NTN, PSP and ART, whose major role is in peripheral neurodevelopment. This family enhance proliferation and survival of enteric neural crest precursor cells and is critical for the development of peripheral sensory nerve. Other growth factors such as bFGF and EGF can enhance proliferation and survival of neural stem cell. CNTF and LIF are critical for differentiation of neural stem cells. |
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| Keywords: | Neurotrophic factors Neural stem cell |
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