白细胞介素2新的功能位点及其中枢镇痛作用

白细胞介素２（ＩＬ－２），不仅是重要的免疫调节因子，而且具有重要的中枢调节作用。本工作表明：（１）ＩＬ－２具有中枢镇痛作用；（２）ＩＬ－２除具有免疫调节作用功能位点外，还存在着另一新的与之相互独立的镇痛功能位点；（３）ＩＬ－２的中枢镇痛作用，主要是由ＩＬ－２第４５位Ｔｙｒ残基以及空间结构上邻近的４４、１１７位Ｐｈｅ等残基共同构成的镇痛功能位点与阿片受体直接结合所介导。本工作提示，细胞因子的多功能性，可能是其相互独立的功能位点作用于不同的受体或受体亚型所致。

A New Domain of Interleukin -2 and Its Analgesic Effect in Central Nervous System

Interleukin-2(IL-2)possesses not only immunoregulatory activity,but also important effect on central nervous system(CNS).Here we report that IL-2 is an analgesic molecule in CNS and suggest that there are two distinct domains in IL- 2 that mediate immune and analgesic activity.It is inferred that the analgesic effect of IL-2 in CNS is mainly mediated through the analgesic domain which is composed of the 45th Tyr-residue,the 4 4th,11 7th Pheresidues and other residues around the 4 5thTyr in tertiary structure,directly binding to the opioid receptors.In addition,we propose that the multiple actions of cytokines might be mediated by interaction of distinct domains with different receptors or receptor subtypes.