| 下丘脑食欲素在药物成瘾中的作用 |
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| 作者姓名： | Han J Li YH Bai YJ Sui N |
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| 作者单位： | 1. 中国科学院心理健康重点实验室,中国科学院心理研究所,北京,100101
2. 中国科学院研究生院,北京,100049 |
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| 基金项目： | 国家重点基础研究发展计划(973计划);国家自然科学基金;中国科学院"西部之光"人才培养计划;国家自然科学基金;中国科学院知识创新工程项目 |
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| 摘 要： | 下丘脑是调控自然奖赏的重要脑区,它能特异性地表达一种神经肽——食欲素(orexin),这种神经肽在药物奖赏中的作用受到广泛关注。在成瘾研究中,发现不同脑区中的食欲素神经元对奖赏和动机行为的调节作用是不相同的:围穹窿区(PFA)和背内侧下丘脑区(DMH)的食欲素神经元主要参与激活应激系统,而外侧下丘脑(LH)的食欲素神经元主要通过激活与奖赏学习相关的大脑环路参与奖赏行为的调控。提示食欲素系统可在延长戒断防止复吸发生中成为新的研究目标,食欲素受体可以作为治疗药物成瘾的一种新的治疗靶标。
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| 关 键 词： | 食欲素 药物成瘾 下丘脑 |
Role of hypothalamic orexin in drug addiction |
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| Han J,Li YH,Bai YJ,Sui N.Role of hypothalamic orexin in drug addiction[J].Progress in Physiological Sciences,2007,38(4):327-330. |
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| Authors: | Han Jin Li Yong-Hui Bai Yun-Jing Sui Nan |
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| Institution: | Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Graduate University of Chinese Academy of Sciences, Beijing 100049,China |
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| Abstract: | Hypothalamus is considered as an important brain region regulating natural rewards. Orexin, a neuropeptide specifically expressed in hypothalamus, arrests investigators' much attention for its function in drug rewards. Orexin neurons in different brain regions exert different roles in regulating reward and motivation in the addiction research: orexin neurons in perifornical area (PFA) and dorsomedial hypothalamus (DMH) are mainly concerned with activating stress system, while orexin neurons in lateral hypothalamus participate in mediating reward-related behavior through activating brain circuitry involved in reward learning. The orexin system may therefore represent a target for preventing relapse to drug seeking during protracted abstinence. And targeting orexin receptors may provide new therapeutic strategies to treat addiction. |
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| Keywords: | orexin addiction hypothalamus |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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