| 钙依赖性突触的可塑性 |
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| 作者姓名： | Dou Y Yan J Wu YY Cui RY Lu CL |
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| 作者单位： | 1. 青岛大学医学院病理生理学教研室,
2. 第二军医大学神经生物学教研室, |
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| 基金项目： | 国家自然科学基金（39670259,
3990080）、军队医药卫生科研基金（96M077, 98M079）资助课题 |
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| 摘 要： | 突触前和突触后细胞内钙离子（Ca^2 ]i)在短时程和长时程突触的可塑性中,发挥着重要的住处传递作用。兴奋后残留Ca^2 ]i,可以激发短时程突触增强。突触前Ca^2 ]i可以影响被抑制的突触前膜囊泡的更新,并准确编码突前和突触后信息,产生截然相反的长时程突触修（ＬＴＰ或ＬＴＤ）。
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| 关 键 词： | 细胞内钙离子 突触 可逆性 学习 记忆 神经元 |
Calcium dependent synaptic plasticity |
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| Dou Y,Yan J,Wu YY,Cui RY,Lu CL.Calcium dependent synaptic plasticity[J].Progress in Physiological Sciences,2001,32(1):35-38. |
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| Authors: | Dou Y Yan J Wu Y Y Cui R Y Lu C L |
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| Institution: | Department of Pathophysiology, Qingdao Medical College, Qingdao 266021. |
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| Abstract: | Recent work shows that the intracellular free Ca2+ concentrations (Ca2+]i) of the presynaptic and postsynaptic neurons play crucial signaling roles in short- and long-term synaptic plasticity. Residual Ca2+]i followed conditioning stimulation may cause short-term synaptic enhancement. Presynaptic Ca2+]i could influence the replacing of presynaptic depressed vesicles, as well as encode the precise relative timing of presynaptic input and postsynaptic activity and generate long-term synaptic modification of opposite polarity(LTP or LTD). |
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