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病毒性心肌炎和扩张性心肌病的研究进展
引用本文:张永珍,陈明哲.病毒性心肌炎和扩张性心肌病的研究进展[J].生理科学进展,2002,33(2):136-141.
作者姓名:张永珍  陈明哲
作者单位:北京大学第三医院内科,北京,100083
摘    要:病毒性心肌炎是一种常见的疾病,一般不引起严重后果。然而在有些病例中可以引起严重的心肌损伤和急性心力衰竭。它有时也可以演变成进行性的慢性心力衰竭。近年的研究致力于阐明病毒感染后心肌务的复杂机制,这些研究证明心肌损伤是由免疫和病毒双重机制所介导的。急性心肌炎可以有不同的临床表现,它也可以是健康青年人的猝死原因。临床和实验研究表明α1-受体阻滞剂、卡替洛尔、维拉帕米、血管紧张素转换酶抑制剂治疗有效。抗病毒药物的应用应受到重视。临床上免疫抑制剂治疗病毒性心肌炎效果不明显,而免疫调节治疗有望成为有意义的治疗方法。

关 键 词:病毒性心肌炎  柯萨奇B病毒  扩张性心肌病  研究进展

Advances of the Study on Viral Myocarditis and Dilated Cardi omyopathy
ZHANG Yong-Zhen,CHEN Ming-Zhe.Advances of the Study on Viral Myocarditis and Dilated Cardi omyopathy[J].Progress in Physiological Sciences,2002,33(2):136-141.
Authors:ZHANG Yong-Zhen  CHEN Ming-Zhe
Abstract:Viral infection of the heart is relatively common and usually of little aversive consequence. It can, however, lead to substantial cardiac damage and severe acute heart failure. It can also evolve into the progressive syndrome of chronic heart failure. Recent studies have gained achievement towards unravelling the complex mechanisms underlying the heart muscle damage that occurs after viral infection. These studies have lent support to both immune and virus mediated (independent of an immune response) cardiac damage. Acute myocarditis can present in various types, and it may be a cause of sudden death in an otherwise healthy young adult. New treatments for viral heart disease are awaited.
Keywords:Myocarditis  Coxsackie B virus  Dilated cardiomyopath
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