抗酶的研究进展

抗酶（antizyme）是当细胞内多胺水平升高时刺激机体合成的一种小分子量调节蛋白,能特异性地与鸟氨酸脱羧酶（omithine decarboxylase,ODC）结合,经泛素非依赖途径被26S蛋白酶体降解,从而使多胺合成减少;抗酶还可以调节多胺转运,以稳定细胞内多胺水平。近年来随着生物技术的不断发展,对抗酶的认识也逐步深入,本文综述了抗酶家族、合成、作用及定位等方面的研究进展。

Progress in the research of antizyme

Antizyme is a small protein induced by elevated intracellular polyamines.Antizyme binds specifically to ornithine decarboxylase(ODC),targeting ODC for ubiquitin-independent degradation by the 26S protosome,which consequently reduces polyamine synthesis.Polyamine transport may also be regulated by antizyme,through which the cellular polyamine levels are maintained.In recent years,more and more studies focus on antizyme with the development of biotechnique.In this article,advancements in the antizyme family,synthesis,function and intracellular location are reviewed.