| p38 MAPKs在细胞周期调控中的作用 |
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| 作者姓名： | Chen Y Miao ZH Ding J |
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| 作者单位： | 中国科学院上海生命科学院上海药物研究所国家新药研究重点实验室肿瘤药理组,上海,201203 |
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| 基金项目： | 中国科学院知识创新工程 (KSCX2 3 0 7 8),国家自然科学基金 (30 2 2 80 32 )资助课题 |
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| 摘 要： | p38丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)作为MAPK家族的成员,传统认为它主要参与调控细胞应激反应和免疫反应。近年来发现它还参与调控细胞的增殖、凋亡和分化。在不同应激刺激下,p38 MAPKs通过多条信号转导通路作用于细胞周期的各个检验点,抑制细胞增殖,阻滞细胞于不同周期。
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| 关 键 词： | MAPK 细胞周期调控 p38丝裂原活化蛋白激酶 信号转导通路 免疫反应 凋亡 细胞增殖 分化 发现 家族 |
The emergent role of p38 MAPKs in the regulation of cell cycle |
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| Chen Y,Miao ZH,Ding J.The emergent role of p38 MAPKs in the regulation of cell cycle[J].Progress in Physiological Sciences,2004,35(4):315-320. |
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| Authors: | Chen Yi Miao Ze-Hong Ding Jian |
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| Institution: | Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Science, Chinese Academy of Sciences, Shanghai. |
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| Abstract: | The p38 MAPKs are members of the MAPK family. Its pathwa y has been traditionally associated with the stress and immune response. More rec ently, it has been reported that the p38 MAPKs pathway can also regulate apoptos is and some differentiation process. It can regulate cellular growth and cell c ycle checkpoints in different ways depending on the cell type and the stimulus. |
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| Keywords: | p38 MAPKs Cell cycle arrest G1/S checkpo int G2/M checkpoint |
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