| 一个新的信号受体家族--Toll/IL-1R家族的研究进展 |
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| 作者姓名： | Chen J Luo XD Yang ZC Chang ZL |
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| 作者单位： | 1. 第三军医大学附属西南医院烧伤研究所,重庆,400038
2. 中国科学院上海细胞生物学研究所,上海,200031 |
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| 基金项目： | 国家自然科学基金重点资助课题!(39830400) |
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| 摘 要： | Ｔｏｌｌ受体最初是在研究果蝇胚胎腹背侧体轴的形成中发现的,由于它与ＩＬ－１受体在结构、功能、信号转导通路上的诸多相似,人们将它们归入一个大的信号受体ｏｌｌ／ＵＩＬ－１Ｒ家族。许多研究均证实,除与胚胎发育有关外,这一信号受体家族的成员在机体对抗外来病原体的天然免疫中起到了重要的作用,尤其是人类Ｔｏｌｌ蛋白在介导内毒素对细胞操作中的作用备受关注。
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| 关 键 词： | 病原识别 Toll／IR－1R受体家族 胚胎发育 |
A new signal receptor family--a review of the current progress of Toll/IL-1R family |
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| Chen J,Luo XD,Yang ZC,Chang ZL.A new signal receptor family--a review of the current progress of Toll/IL-1R family[J].Progress in Physiological Sciences,2000,31(4):305-310. |
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| Authors: | Chen J Luo X D Yang Z C Chang Z L |
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| Institution: | Institute of Burn Research, Southwest Hospital, Third Military Medical College, Chongqing 400038. |
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| Abstract: | Toll receptor was first identified in studies of dorsalventral polarity formation of drosophila embryo. As its similarity in structure, function and signal transduction pathway to the IL-1 receptor, Toll becomes a member of a new signal receptor family--the Toll/IL-1R family. Besides participating in embryonic development, this signal receptor family also plays a key role in triggering innate defenses against pathogens, in which the function of human Toll protein in the pathogenesis of LPS is especially interested. |
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| Keywords: | Toll |
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