蛋白质组学技术在感染研究中的应用

蛋白质组学的目标在于阐明特定生物体、组织、细胞或亚细胞结构中全部蛋白质的表达模式和功能模式,其技术平台由高通量的蛋白质分离技术、鉴定技术和生物信息学组成。在许多研究领域,蛋白质组学技术为阐明疾病过程和生命现象的分子机制提供了全面、网络和动态的蛋白质组信息。感染是重要的基本致病因素之一,蛋白质组学的研究策略和技术方法有利于快速分离鉴定病原体蛋白质组、宿主免疫细胞蛋白质组、感染相关蛋白、疫苗候：选抗原蛋白、生物标志物和药物靶标,从而明显加快病原体、宿主反应、感染发病机制以及感染预防、诊断和治疗等相关研究的进程。

Application of proteomic technology in the study on infection

Proteomics is aimed to illuminate the expression and function pattern of global protein in given organism,tissue,cell or subcellular structure.And its technical platform consists of highthoughout protein separation and indentification technology combinated with bioinformatic technology.In many research fields,proteomic technology provided comprehensive,dynamic,and reticular proteome information critical for the understanding of the molecular mechanism of disease processes or life phenomena.As infection is one of the most basic etiological factors,the strategy and technology of proteomics would be very useful in isolation and identification of pathogen proteome,host immune cellular proteome,infection-related proteins,vaccine candidate antigens,biomarkers and drug target proteins,which would then obviously promote the processes of infection-related research,such as pathogen,host response,mechanism of infection as well as the prophylaxis,diagnosis,and therapy of infection.