药物蛋白质组学与药物发现

21世纪，科学家面临着从基因组到蛋白质组的转变，蛋白质组学是基因组和药物发现的效率。药物蛋白质组学研究不仅有助于发现治疗的可能靶点，也将明显提高药物发现的效率。药物蛋白质组学的研究内容，在临床前包括发现新的治疗靶点和发现针对所有靶点的全部化合物，在临床研究方面应包括药物作用的特异蛋白作为诊断和治疗的标志，或以蛋白质谱的差异来分类者。本文主要综述了蛋白质组学在药物靶点的发现和确认，以有药物发现过程中最有关的技术物研究进展。

Pharmacoproteomics and Drug Discovery

In the 21 century, scientists worked in biomedical research areas face a tremendous transformation from genome to proteome. Proteomics is a bridge crossing genome to drug discovery. Proteomics studies will provide potential targets for therapeutic usage and moreover increase the efficiency of the downstream drug discovery process. Pharmacoproteomics should be defined as the discovery and validation of all possible targets and all potential compounds to these targets. In clinical studies, it should be involved in determining the specific proteins as therapeutics and diagnostic markers, subtyping patients on the basis of protein analysis. In this article, the proteome technology and research progress in targets and drug discovery were reviewed.