| 小胶质细胞对成年哺乳动物神经发生的调节作用 |
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| 作者姓名： | Liu ZQ Zhang JT Tang MK |
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| 作者单位： | 1. 北京中医药大学,北京,100102
2. 中国医学科学院药物研究所,北京,100050 |
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| 基金项目： | 国家自然科学基金,教育部留学回国人员基金;教育部创新团队发展计划项目 |
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| 摘 要： | 成年哺乳动物的神经发生现象被大量研究证实,影响和调节神经发生的因素也逐渐被揭示.小胶质细胞是中枢神经系统重要的"免疫"细胞,它对神经发生具有广泛的调节作用.一方面,小胶质细胞通过与T细胞作用,或者释放神经生长因子促进神经发生;另一方面,激活的小胶质细胞释放一些细胞因子,形成一个不利于新生神经细胞的生存环境.本文对有关小胶质细胞影响神经发生的最新研究进展进行综述,这些研究进展将为理解小胶质细胞与神经发生的关系以及探索促进神经损伤修复的措施提供重要线索.
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| 关 键 词： | 小胶质细胞 神经发生 细胞因子 |
Regulation of microglia on neurogenesis in adult mammals |
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| Liu ZQ,Zhang JT,Tang MK.Regulation of microglia on neurogenesis in adult mammals[J].Progress in Physiological Sciences,2011,42(1):21-25. |
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| Authors: | Liu Zhi-Qiang Zhang Jun-Tian Tang Min-ke |
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| Institution: | LIU Zhi-Qiang1,ZHANG Jun-Tian2,TANG Min-ke1,(1Beijing University of Chinese Medicine,Beijing 100102,China,2Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing 100050,China) |
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| Abstract: | Adult neurogenesis had been confirmed in rodents and other mammals for decades.The mechanisms underlying neurogenesis have been investigated extensively in recent years.Microglial cells,an immuno-cell in the central nervous system,have been found playing important roles in modulating the process of adult neurogenesis.The inflammatory microenvironment contributed by microglia are harmful to the survival of new born neurons.On the other hand,by interacting with T cells,microglia could act as a trophic factor ... |
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| Keywords: | microglia neurogenesis cytokine |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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