肥胖与神经调节

机体的能量获取和能量消耗,在一定时期内,是处于一种相对平衡的状态;获取的能量等于消耗的能量,在这一调节中,神经系统起有重要的作用,如果获取的能量（进食）大于消耗的能量,将产生肥胖,由于很多疾病与肥胖的产生有密切的关系,因此,对能量平衡调节的研究越来越受到重视。本文简要总结了近年来这方面的研究进展,内容包括：（１）饱感的产生与进食的终止;（２）机体脂肪储存信号与进食的调节;（３）与进食有关的中枢;（４）下丘脑中传递与进食有关信息的一级和二级神经元;（５）与临床的关系。

Obesity and the central nervous system regulation

There are increasing evidences to show that central nervous system is involved in the regulation of energy homeostasis. Energy intake is usually matched to energy expenditure over a period of time. Obesity occurs when the amount of energy intake (or food intake) is more than the energy expenditure. Because of the enormous tolls on human health taken by obesity and related disorders, an improved understanding of the control of food intake is an important priority. The aim of this article is to briefly review the advances in recent years on long term maintenance of energy homeostasis and the role of central nervous system. In the present review, the following contents are included: (1) satiety and its production, (2) adiposity signals and the regulation of food intake, (3) nuclei in central nervous system involved in food intake, (4) the first and the second order neuronal signaling in hypothalamus on control of food intake and (5) clinic implications.