| 核受体FXR:一种新型代谢调节因子 |
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| 作者姓名： | Zhang XY Guan YF |
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| 作者单位： | 北京大学医学部生理学与病理生理学系,北京大学糖尿病中心,北京,100083 |
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| 摘 要： | 法尼酯衍生物X受体(farnesoid X receptor,FXR)是一种胆汁酸受体,属于核受体超家族成员。FXR通过调控一系列基因的表达,在胆汁酸、脂质和糖代谢中发挥重要作用,进而有望成为治疗一系列代谢性疾病的药物靶点。本文将就FXR的相关研究进展作一综述。
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| 关 键 词： | 法尼酯衍生物X受体 胆汁酸代谢 脂质代谢 糖稳态 |
Farnesoid X receptor (FXR): a novel regulative factor involved in metabolism |
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| Zhang XY,Guan YF.Farnesoid X receptor (FXR): a novel regulative factor involved in metabolism[J].Progress in Physiological Sciences,2007,38(3):219-223. |
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| Authors: | Zhang Xiao-Yan Guan You-Fei |
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| Institution: | Department of Physiology and Pathophysiology, Peking University Health Science Center, Peking University Diabetes Center, Beijing 100083 ,China |
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| Abstract: | Farnesoid X receptor(FXR), a bile acid receptor,belongs to nuclear hormone receptor superfamily. FXR regulates expression of a diversity of target genes controlling bile acid homeostasis and lipid and carbohydrate metabolism. Studies on FXR will help to clarify its potential as a pharmacological target for therapeutic applications in many metabolic diseases. |
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| Keywords: | farnesoid X receptor bile acid metabolism lipid metabolism glucose homeostasis |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
