Modulation of malaria-induced immunopathology by concurrent gastrointestinal nematode infection in mice |
| |
Authors: | M Segura C Matte N Thawani Z Su MM Stevenson |
| |
Institution: | Centre for the Study of Host Resistance, Department of Medicine, Research Institute of the McGill University Health Centre and Centre for Host–Parasite Interactions, Institute of Parasitology, McGill University, Montreal, Que., Canada |
| |
Abstract: | We investigated malaria-associated pathology in mice co-infected with Heligmosomoides polygyrus (Hp) and Plasmodium chabaudi AS (Pc). Despite higher peak parasitemia, co-infected wild-type (WT) C57BL/6 mice displayed similar body weight losses, malarial anaemia, and tissue damage but less severe hypothermia and hypoglycaemia, and earlier reticulocytosis than Pc-infected WT mice. Co-infected STAT6−/− mice, deficient in nematode-induced Th2 responses, experienced similar peak parasitemias and generally suffered malaria-associated pathology to a similar degree as co-infected WT mice. These data indicate a complex relationship amongst helminths, malaria and host immune responses resulting in modulation of some but not all aspects of malaria-associated pathology. |
| |
Keywords: | Co-infection Plasmodium Malaria Gastrointestinal nematodes Pathology Th2 cytokines Immunopathology |
本文献已被 ScienceDirect 等数据库收录! |
|