Modulation of neurotransmission by reciprocal synapse-glial interactions at the neuromuscular junction |
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Authors: | Auld Daniel S Colomar Aurore Bélair Eve-Lyne Castonguay Annie Pinard Audrée Rousse Isabelle Thomas Sébastien Robitaille Richard |
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Institution: | 1. Département de physiologie, Université de Montréal, Centre de Recherche en Sciences Neurologiques, PO-Box 6128, Station Centre-Ville, Montréal, Québec, H3C 3J7, Canada
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Abstract: | Perisynaptic Schwann cells are glial cells that are closely associated with pre- and postsynaptic elements of the neuromuscular junction. Recent evidence shows that these cells detect and modulate neurotransmission in an activity-dependent fashion. Through G-protein signalling and Ca2+ released from internal stores they can decrease or increase neurotransmitter release, respectively. Thus, they help to establish the level of neurotransmission associated with activity dependent short-term synaptic plasticity. We discuss evidence implicating perisynaptic Schwann cells as being active partners in neurotransmission at the neuromuscular junction, with emphasis on the modulation of short-term plasticity and potential implications for long-term changes. |
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