Cellular energy sensing and signaling by AMP-activated protein kinase |
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Authors: | William W Winder David M Thomson |
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Institution: | (1) Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA |
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Abstract: | AMP-activated protein kinase (AMPK) is an energy sensing/signaling protein that, when activated, increases ATP production
by stimulating glucose uptake and fatty acid oxidation while at the same time inhibiting ATP=consuming processes such as protein
synthesis. Chronic activation of AMPK inhibits expression of lipogenic enzymes in the liver and enhances expression of mitochondrial
oxidative enzymes in skeletal muscle. Deficiency of muscle LKB1, the upstream kinase of AMPK, results in greater fluctuation
in energy charge during muscle contraction and decreased capacity for exercise at higher work rates. Because AMPK enhances
both glucose uptake and fatty acid oxidation in skeletal muscle, it has become a target for prevention and treatment of type
2 diabetes and obesity. |
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Keywords: | AMPK LKB1-STRAD-MO25 glucose uptake fatty acid oxidation protein synthesis type 2 diabetes |
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