Polymorphism in chemokine receptor genes and risk of acute myocardial infarction in North Indian population |
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| Authors: | Neha Singh Nakul Sinha Sudeep Kumar Chandra M Pandey Suraksha Agrawal |
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| Institution: | (1) Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, Uttar Pradesh, India;(2) Sahra Hospital, Lucknow, 226010, Uttar Pradesh, India;(3) Department of Biostatistics and Health Informatics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, Uttar Pradesh, India;(4) Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, Uttar Pradesh, India |
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| Abstract: | Chemokines regulates the trafficking of leukocytes to the site of inflammation hence may be implicated in cardiac events.
Currently no consistent effects have been revealed their role in acute myocardial infarction (MI). The aim of current study
was to investigate the impact of human chemokine receptor genetic variants, CCR5-Δ32 insertion/deletion, CCR5-59029-A/G, CX3CR1-V249I
and CX3CR1-T280 M on acute MI. 230 acute MI and 300 controls were examined. Patients carrying CCR5-Δ32 genotype were at three
times higher risk of developing MI odds ratio (OR, 3.24, CI 1.127–9.356, P = 0.04). Significant association was found with risk of acute MI in recipients who possessed homozygous 59029-A allele (OR
1.47, CI 1.03–2.09, P = 0.03). While CX3CR1-I249 and M280 were found to be protective in MI patients with OR 0.46, CI 0.32–0.66, P < 0.0001 and OR 0.36, CI 0.24–0.55, P < 0.0001, respectively. It might be possible that risk of acute MI is associated with genetic variation in chemokine receptors,
i.e., CCR5 and CX3CR1. |
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