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Progression of O6-methylguanine-DNA methyltransferase and temozolomide resistance in cancer research |
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| Authors: | Guan Jiang Ai-Jun Jiang Yong Xin Lian-Tao Li Qian Cheng Jun-Nian Zheng |
| Institution: | 1. Jiangsu Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, 221002, China 3. Center for Disease Control and Prevention of Xuzhou City, Xuzhou, 221002, China 2. Department of Stereotactic Radiosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, 221002, China |
| Abstract: | Temozolomide (TMZ) is an alkylating agent that is widely used in chemotherapy for cancer. A key mechanism of resistance to TMZ is the overexpression of O6-methylguanine-DNA methyltransferase (MGMT). MGMT specifically repairs the DNA O6-methylation damage induced by TMZ and irreversibly inactivates TMZ. Regulation of MGMT expression and research regarding the mechanism of TMZ resistance will help rationalize the clinical use of TMZ. In this review, we provide an overview of recent advances in the field, with particular emphasis on MGMT structure, function, expression regulation, and the association between MGMT and resistance to TMZ. |
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