Cardiac matrix remodeling following intracoronary cell transplantation in dilated cardiomyopathic rabbits |
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Authors: | Bo Jin Xin-Ping Luo Huan-Chun Ni Yong Li Hai-Ming Shi |
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Institution: | (1) Department of Cardiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China; |
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Abstract: | Cellular cardiomyoplasty has been proposed as a promising therapeutic strategy for chronic heart failure. Previous studies
focused on structural changes in cardiomyocytes to explain the potential benefits for contractile function. However, limited
information is available about the cardiac matrix remodeling following cell transplantation in dilated cardiomyopathy (DCM).
Here, we established a new animal model of intracoronary bone marrow mononuclear cells (BMMNCs) transplantation to explore
extracellular matrix remodeling in adriamycin-induced cardiomyopathic rabbits. In vivo studies demonstrated that BMMNCs transplantation
can dramatically delay the progress of collagen metabolism and decrease myocardial collagen volume fraction. The beneficial
effects were mediated by attenuating stress-generated over-expression of matrix metalloproteinases (MMPs) in ventricular remodeling.
Improved cardiac function may be contributed in part by stem-associated inhibition of extracellular matrix remodeling. |
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