Study on the association of p53 codon 72 polymorphisms with risk of gastric cancer in high incidence Hexi area of Gansu Province in China |
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Authors: | Zhu Ke-Xiang Li Yu-Min Li Xun Zhou Wen-Ce Shan Yong Liu Tao |
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Institution: | (1) Department-2 of General Surgery, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China;(2) Key Laboratory of Digestive System, The Second Hospital of Lazhou University, Lanzhou, 730000, Gansu, China |
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Abstract: | To investigate the possible association of P53 codon 72 Arg/Pro polymorphisms with risk of gastric cancer in the high incidence
Hexi area of Gansu province in China. Blood samples from 140 patients with gastric carcinoma and 125 healthy controls were
collected in Hexi area of Gansu province. Polymorphism of P53Arg72Pro was genotyped by PCR-TaqMan. For detection Helicobacter pylori infection, Warhin–Starry staining was used. Three kinds of polymorphisms of P53Arg72Pro were Arg/Arg, Arg/Pro, Pro/Pro. The
frequencies in gastric cancer group were 15.7, 60.0, 24.3%, and the frequencies in healthy controls were 25.6, 54.4, 20.0%,
respectively. P53 codon 72 Pro carrier genotype (Arg/Pro + Pro/Pro) increased risk of gastric carcinoma with an odds ratio
1.840 (95% CI: 1.006–3.387). Helicobacter pylori infection rate was 68.6% in patients group and 50.4% in healthy controls. Helicobacter pylori infection rate in gastric cancer patients was remarkably higher than that in the controls (OR: 2.147, 95% CI: 1.302–3.541,
P = 0.003). Stratification analysis showed that P53 codon 72 Pro carrier genotype with Helicobacter pylori infection was significantly higher in cases than that in the controls (OR: 4.182, 95% CI: 1.850–9.454). P53Arg72Pro polymorphisms
could be a risk factor for gastric cancer in high incidence Hexi area of Gansu Province in China. P53 codon 72 Pro carrier
genotype and Helicobacter pylori positive infection may have a synergistic effect on gastric cancer in high incidence Hexi area of Gansu Province in China. |
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