Class 1 integron in staphylococci |
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Authors: | Zhenbo Xu Lin Li Lei Shi Mark E Shirtliff |
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Institution: | (1) College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China;(2) Department of Microbial Pathogenesis, Dental School, University of Maryland, Baltimore, MD 21201, USA;(3) Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan;(4) Department of Microbiology and Immunology, School of Medicine, University of Maryland, Room #9209, 650W. Baltimore Street, Baltimore, MD 21201, USA; |
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Abstract: | As a major concern in public health, methicillin-resistant staphylococci (MRS) still remains one of the most prevalent pathogens
that cause nosocomial infections throughout the world and has been recently labeled as a “super bug” in antibiotic resistance.
Thus, surveillance and investigation on antibiotic resistance mechanisms involved in clinical MRS strains may raise urgent
necessity and utmost significance. As a novel antibiotic resistance mechanism, class 1 integron has been identified as a primary
source of antimicrobial resistance genes in Gram-negative organisms. However, most available studies on integrons had been
limited within Gram-negative microbes, little is known for clinical Gram-positive bacteria. Based on series studies of systematic
integrons investigation in hundreds of staphylococci strains during 2001–2006, this review concentrated on the latest development
of class 1 integron in MRS isolates, including summary of prevalence and occurrence of class 1 integron, analysis of correlation
between integron and antibiotic resistance, further demonstration of the role integrons play as antibiotic determinants, as
well as origin and evolution of integron-associated gene cassettes during this study period. |
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