Isolation and Characterization of Ubiquitin-activating Enzyme E1-domain Containing 1, UBE1DC1 |
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Authors: | Tonghai?Dou Shaohua?Gu Jianping?Liu Fei?Chen Li?Zeng Lingchen?Guo Yi?Xie Email author" target="_blank">Yumin?MaoEmail author |
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Institution: | (1) State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, 200433, People’s Republic of China |
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Abstract: | Ubiquitin and other ubiquitin-like proteins play important roles in post-translational modification. They are phylogenetically
well-conserved in eukaryotes. Activated by other proteins, ubiquitin and ubiquitin-like proteins can covalently modify target
proteins. The enzymes responsible for the activation of this modification have been known to include UBA1, SAE2, UBA3, SAE1
and ULA1. Here we report a new ubiquitin activating enzyme like cDNA, named ubiquitin activating enzyme E1-domain containing
1 (UBE1DC1), whose cDNA is 2654 base pairs in length and contains an open reading frame encoding 404 amino acids. The UBE1DC1
gene consists of 12 exons and is located at human chromosome 3q22. The result of RT-PCR showed that UBE1DC1 is expressed in most of human tissues.
These two authors contributed equally to this paper.
The nucleotide sequence reported in this paper has been submitted to GenBank under accession number AY253672. |
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Keywords: | expression UBE1DC1 ubiqitin-activating |
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