The sensitization of glioma cells to cisplatin and tamoxifen by the use of catechin |
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Authors: | Amal Shervington Vidya Pawar Sharad Menon Dipti Thakkar Rahima Patel |
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Institution: | (1) Brain Tumour North West, Faculty of Science, University of Central Lancashire, Preston, UK |
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Abstract: | Telomerase expression strongly correlates with the grade of malignancy in glioma with inhibition illustrating a definite increase
in chemosensitivity. This study was designed to investigate the effects of a green tea derivative, epigallocatechin-3-gallate
(EGCG); together with either cisplatin or tamoxifen in glioma, and to investigate whether these effects are mediated through
telomerase suppression. EGCG showed a significant cytotoxic effect on 1321N1 cells after 24 h and on U87-MG cells after 72 h
(P < 0.001) without significantly affecting the normal astrocytes. Treatment with EGCG inhibited telomerase expression significantly
(P < 0.01) and enhanced the effect of cisplatin and tamoxifen in both 1321N1 (P < 0.01) and U87-MG (P < 0.001) cells. EGCG, as a natural product has enormous potential to be an anti-cancer agent capable of enhancing tumour
cell sensitivity to therapy. |
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Keywords: | Epigallocatechin-3-gallate (EGCG) Telomerase Glioma Cisplatin Tamoxifen |
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