Molecular mechanisms of endotoxin activity |
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Authors: | Jens Schletter Holger Heine Artur J Ulmer Ernst T Rietschel |
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Institution: | (1) Forschungsinstitut Borstel, Institut für Experimentelle Biologie und Medizin, Parkallee 22, D-23845 Borstel, Germany |
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Abstract: | Endotoxin (lipopolysaccharide, LPS), a constitutent of the outer membrane of the cell wall of gramnegative bacteria, exerts
a wide variety of biological effects in humans. This review focuses on the molecular mechanisms underlying these activities
and discusses structure-function relationships of the endotoxin molecule, its interaction with humoral and cellular receptors
involved in cell activation, and transmembrane and intra-cellular signal transduction pathways. |
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Keywords: | Endotoxin Lipopolysaccharide CD14 LPS-binding protein |
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