Rapid decrease of ATP content in intact cells of Saccharomyces cerevisiae after incubation with low concentrations of sulfite |
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| Authors: | Karl-Ludwig Schimz Helmut Holzer |
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| Institution: | (1) Institute für Toxikologie und Biochemie der Gesellschaft für Strahlen- und Umweltforschung mbH München, Ingolstädter Landstr. 1, D-8042 Neuherberg/Post Oberschleißheim, Germany;(2) Biochemisches Institut der Universität Freiburg, Hermann-Herderstr. 7, D-7800 Freiburg i. Br., Germany;(3) Present address: Institut für Biotechnologie der Kernforschungsanlage Jülich, Postfach 1913, D-5170 Jülich 1, Germany |
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| Abstract: | Sulfite, at concentrations above 1 mM and at a pH below 4, caused cell death in Saccharomyces cerevisiae X2180 as measured by the colony-forming capacity. A rapid decrease in the ATP content was observed prior to cellular death. The depletion of ATP was reversible and the lethal effect could be prevented if the cells were exposed to sulfite for periods of less than 1 h. Extent and rate of ATP depletion were dependent on time, pH value, temperature and sulfite concentrations. |
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| Keywords: | Sulfur dioxide Sulfite Air polluting substances Saccharomyces cerevisiae ATP hydrolysis Reversibility of sulfite effect |
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