河蚌外套膜组织培养细胞分泌的珍珠质的药理作用

本文研究河蚌外套膜组织培养细胞分泌珍珠质的药理作用。组织培养后的培养液，能缩短小白鼠出血时间。用组织培养后的培养液及组织块水解液，对大鼠离体子宫及蟾蜍离体心脏收缩有增强作用，对兔离体小肠有抑制作用。这些药理作用与培养液中牛磺酸含量变化一致。实验结果表明，河蚌分泌珍珠质的细胞，在离体人工培养条件下，能旺盛地分泌珍珠质，分泌的珍珠质具有天然珍珠相同的一些药理作用。

THE PHARMACOLOGICAL FUNCTIONS OF NACRUM SE-CRETED BY THE CULTUREDPALLIUMCELLS OF FRESH WATER OYSTEK

The pharmacological function of nacrum secreted by cultured pallium cells of a freshwater oyster was examined.Injections of the cultured mantle tissue solution into micecan reduce the bleeding duration after their tails being cut.The cultured solution and thehydrolysed cultured solution can strengthen the systole of the rat uterus( in vitro)andthe toad heart( in vitro),but suppress the systole of rabbit small in testine. Thispharmacological function changes with taurine content in the cuItured solution. The results indicate that the oyster cells secret nacrum vigorously under culturedconditions in vitro,and the secreted nacrum has the same pharmacological function asthe natural pearls.