Evaluation of Some Trypanostatic Agents by Means of Herpetomonas culicidarum |
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Authors: | NATHAN GROSSOWICZ GOORY RASOOLY |
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Institution: | Dept. of Bacteriology, The Hebrew University-Hadassah Medical School, Jerusalem |
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Abstract: | SYNOPSIS. A rapid quantitative method for measuring trypanostatic activity by means of the nonpathogenic flagellate Herpetomonas culicidarum is described. Of the known trypanocidal agents tested, pentamidine was the most active; stilbamidine and propamidine somewhat less active. H. culicidarum is more resistant to these agents than are some pathogenic hemoflagellates. Two new antifungal antibiotics, nystatin and heptamycin (a candicidin-like antibiotic), had powerful trypanostatic activity in vitro. The potential trypanostatic activity of antifungal agents is noted. |
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