RAS蛋白在有丝分裂信号转导中的作用

致癌基因ｒａｓ编码的ＲＡＳ蛋白参与了多种细胞因子调控的有丝分裂过程。抗ＲＡＳ抗体能抑制细胞正常的有丝分裂。ｒａｓ基因转化的成纤维细胞ＮＩＨ３Ｔ３还具有在无血清和生长因子刺激下自发完成细胞周期的能力。在这种细胞中有活性氧的生成，抗氧化剂能抑制该细胞的有丝分裂。ＲＡＳ蛋白在有丝分裂的信号转导中参与了多条途径，是信号转导的重要组织者

The Role of RAS in Mitogenic Signaling

RAS encoded by ras was involved in mitosis stimulated by many factors. Anti RAS can inhibit normal mitosis. Ras transformed fibroblast NIH3T3 accomplishes cell cycle in the medinm absence of serum and growth factor. Reactive oxygen was produced in the ras transformed cell. Antioxidant could inhibit the mitosis of the cell. RAS is the center of signaling.