| 家蝇幼虫抗菌肽MDL-2对细菌细胞渗透性及代谢功能影响 |
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| 引用本文： | 宫霞,王兰芳,乐国伟.家蝇幼虫抗菌肽MDL-2对细菌细胞渗透性及代谢功能影响[J].氨基酸和生物资源,2011,33(3):1-5,9. |
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| 作者姓名： | 宫霞 王兰芳 乐国伟 |
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| 作者单位： | 上海商学院食品学院,上海,200235;同济大学基础医学院预防医学教研室,上海,200092;江南大学食品学院,无锡,214036 |
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| 基金项目： | 上海市教委科研创新项目，中央级科研院所基础性专项资金工作项目重点项目 |
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| 摘 要： | 研究了家蝇幼虫抗菌肽MDL-2与细菌相互作用时,抗菌肤MDL-2对细菌细胞壁的溶解作用、细胞膜渗透性和代谢的影响.抗菌肽MDL-2在抗菌过程中首先与细菌的细胞壁相互作用,使其破裂,抗菌肽对革兰氏阴性细菌大肠杆菌细胞壁的作用有浓度依赖性,而对革兰氏阳性细菌金黄色葡萄球菌MDL-2在较低的浓度时即可发生细胞壁破坏作用;抗菌...
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| 关 键 词： | 家蝇幼虫 抗菌肽 渗透性 β-半乳糖苷酶 代谢 |
Effect of Antimicrobial Peptide MDL-2 from Musca domestica Larvae on Permeability and Metabolism of Bacteria |
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| GONG Xia,WANG Lan-fang,LE Guo-Wei.Effect of Antimicrobial Peptide MDL-2 from Musca domestica Larvae on Permeability and Metabolism of Bacteria[J].Amino Acids & Biotic Resources,2011,33(3):1-5,9. |
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| Authors: | GONG Xia WANG Lan-fang LE Guo-Wei |
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| Institution: | 1.Department of Food Science,Shanghai Business School,Shanghai 200235; 2.School of Medicine,Tongji University,Shanghai 200092;3.School of Food Science,Jiangnan University,Wuxi 214036,China) |
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| Abstract: | Effect of antimicrobial peptide MDL-2 from Musca domestica larvae on dissolution and permeability and metabolism of bacteria were investigated.The cell wall of bacteria was ruptured by interaction of antimicrobial peptide MDL-2 with bacteria.Gram-negative bacteria E.coli had concentration-dependency when antibacterial peptide MDL-2 assembled to certain concentration on cell outer membrane.The cell wall of Gram-positive bacteria S.aureus were fallen apart in lower concentration of MDL-2.The S-type graph showed synergism while MDL-2 interplayed with cytoplasmic membrane of S.aureus.Metabolism function of bacteria was interfered with antibacterial peptide MDL-2,so bacteria were accelerated death. |
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| Keywords: | Musca domestica larvae antibacterial peptide permeability β-galactosidase metabolism |
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