| 响应曲面优化醇法提取桑叶黄酮工艺研究 |
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| 引用本文： | 章华伟,陈星宇,凌春英.响应曲面优化醇法提取桑叶黄酮工艺研究[J].氨基酸和生物资源,2010,32(3):76-79,86. |
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| 作者姓名： | 章华伟 陈星宇 凌春英 |
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| 作者单位： | 浙江工业大学药学院,杭州,310014;浙江工业大学药学院,杭州,310014;浙江工业大学药学院,杭州,310014 |
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| 基金项目： | 浙江省科技厅项目，浙江省教育厅科研基金 |
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| 摘 要： | 以含水乙醇为溶剂,在单因素试验基础上,采用响应曲面法优化提取桑叶黄酮工艺条件。结果表明,醇法提取桑叶黄酮的最优工艺条件为:乙醇体积分数71.75%、提取温度67.1℃、料液比23.2:1(醇溶液:桑叶粉,mL:g)、提取时间150 min、提取次数2,桑叶黄酮得率为2.37%。验证试验表明,该优化工艺稳定,与模型预测值相符。
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| 关 键 词： | 桑叶 黄酮 响应曲面法 提取工艺 |
Optimization of Alcoholic Extraction of Flavonoids from Mulberry Leaves Using Response Surface Methodology |
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| ZHANG Hua-wei,CHEN Xing-yu,LING Chun-ying.Optimization of Alcoholic Extraction of Flavonoids from Mulberry Leaves Using Response Surface Methodology[J].Amino Acids & Biotic Resources,2010,32(3):76-79,86. |
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| Authors: | ZHANG Hua-wei CHEN Xing-yu LING Chun-ying |
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| Institution: | ZHANG Hua-wei,CHEN Xing-yu,LING Chun-ying(School of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China) |
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| Abstract: | On the basis of single factor experiment,response surface methodology(RSM) was applied to optimize extraction of flavonoids from mulberry leaves using alcoholic solution.The results showed that the optimized extraction conditions were 71.75% of ethanol,extraction temperature at 67.1 ℃,ratio of solvent to material of 23.2:1(mL·g-1),extraction time of 150 min and extracted two times.Under these extraction conditions,the yield of flavoniods reached at 2.37%,which agreed with the predicted value and indicated the suitability of RSM in optimizing the extraction of flavonoids from mulberry leaves. |
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| Keywords: | mulberry leaves flavonoids response surface methodology extraction |
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