| 抗肿瘤小分子多肽的研究进展 |
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| 引用本文： | 张冉,劳兴珍,郑珩.抗肿瘤小分子多肽的研究进展[J].氨基酸和生物资源,2012,34(4):42-46. |
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| 作者姓名： | 张冉 劳兴珍 郑珩 |
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| 作者单位： | 中国药科大学,生命科学与技术学院,江苏,南京,210009 |
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| 基金项目： | 国家高技术研究发展计划 |
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| 摘 要： | 抗肿瘤小分子多肽具有分子量小、低毒性、高活性、易于穿透肿瘤细胞等特点,一些抗肿瘤小分子多肽已进入临床研究,成为肿瘤药物研发的新热点。本文从抗肿瘤小分子多肽的不同来源途径、结构改造及生物活性等方面,对其近年来的研究进展作简要概述。
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| 关 键 词： | 抗肿瘤 小分子多肽 噬菌体肽库 化学合成肽库 |
Research Progress on Small-Molecule Antitumor Peptides |
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| ZHANG Ran
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LAO Xingzhen
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ZHENG Heng.Research Progress on Small-Molecule Antitumor Peptides[J].Amino Acids & Biotic Resources,2012,34(4):42-46. |
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| Authors: | ZHANG Ran LAO Xingzhen ZHENG Heng |
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| Abstract: | Antitumor peptides have the characteristics of small molecular weight,low toxicity,high activity,easily penetrating the tumor cells.Small-molecule antitumor peptides have entered clinical research,becoming the new hotspot of cancer drug development.In this paper,small-molecule antitumor peptides from different sources are summarized according to their structure transformation and biological activity. |
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| Keywords: | antitumor small molecule peptides phage display peptide library chemical synthetic peptide library |
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