| 天冬氨酸家族主要氨基酸高产菌株的选育策略 |
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| 引用本文： | 吴瑶瑶,裘娟萍.天冬氨酸家族主要氨基酸高产菌株的选育策略[J].氨基酸和生物资源,2012,34(1):35-41. |
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| 作者姓名： | 吴瑶瑶 裘娟萍 |
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| 作者单位： | 浙江工业大学生物与环境工程学院,浙江杭州,310014;浙江工业大学生物与环境工程学院,浙江杭州,310014 |
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| 摘 要： | L-苏氨酸与L-赖氨酸是L-天冬氨酸家族氨基酸(AFAAs)中的重要成员,近年来由于其在食品、化妆品、动物饲料添加剂等方面的广泛应用而备受关注,市场需求逐年上升。运用代谢工程手段构建高产菌,可有效地提高L-苏氨酸和L-赖氨酸的生产水平。本文详述了L-苏氨酸与L-赖氨酸的合成途径、调控机制以及两种氨基酸高产菌株的构建策略。
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| 关 键 词： | L-苏氨酸 L-赖氨酸 代谢工程 |
Metabolic Engineering Strategies of Bacterial Strains for Overproduction of L-Threonine and L-Lysine |
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| WU Yaoyao
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QIU Juanping.Metabolic Engineering Strategies of Bacterial Strains for Overproduction of L-Threonine and L-Lysine[J].Amino Acids & Biotic Resources,2012,34(1):35-41. |
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| Authors: | WU Yaoyao QIU Juanping |
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| Institution: | (College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou 310014,Zhejiang,China) |
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| Abstract: | L-Threonine and L-lysine,two of the L-aspartate family amino acids（AFAAs）,have attracted great attention because of their wide application in industries of food,animal feeding and cosmetics.Metabolic engineering of bacterial strains significantly improved the production of L-threonine and L-lysine.Here,biosynthetic pathways and regulations of L-threonine and L-lysine are summarized.The strategies of metabolic engineering for the development of L-threonine and L-lysine overproducers are also discussed. |
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| Keywords: | L-threonine L-lysine metabolic engineering |
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