Bidirectional modification of presynaptic neuronal excitability accompanying spike timing-dependent synaptic plasticity |
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Authors: | Li Cheng-yu Lu Jiang-teng Wu Chien-ping Duan Shu-min Poo Mu-ming |
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Institution: | Institute of Neuroscience, Chinese Academy of Sciences, Shanghai Institute of Biological Sciences. |
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Abstract: | Correlated pre- and postsynaptic activity that induces long-term potentiation is known to induce a persistent enhancement of the intrinsic excitability of the presynaptic neuron. Here we report that, associated with the induction of long-term depression in hippocampal cultures and in somatosensory cortical slices, there is also a persistent reduction in the excitability of the presynaptic neuron. This reduction requires postsynaptic Ca(2+) elevation and presynaptic PKA- and PKC-dependent modification of slow-inactivating K(+) channels. The bidirectional changes in neuronal excitability and synaptic efficacy exhibit identical requirements for the temporal order of pre- and postsynaptic activation but reflect two distinct aspects of activity-induced modification of neural circuits. |
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