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Curcumin nanofibers for the purpose of wound healing |
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| Authors: | Narges Fereydouni Majid Darroudi Jebrail Movaffagh Azadeh Shahroodi Alexandra E Butler Shiva Ganjali Amirhossein Sahebkar |
| Institution: | 1. Student Research Committee, Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Narges Fereydouni and Majid Darroudi are the co-first authors.;2. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Narges Fereydouni and Majid Darroudi are the co-first authors.;3. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;4. Diabetes Research Center, Qatar Biomedical Research Institute, Doha, Qatar;5. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;6. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |
| Abstract: | Poor wound healing is a highly prevalent clinical problem with, as yet, no entirely satisfactory solution. A new technique, termed electrospinning, may provide a solution to improve wound healing. Due to their large surface area to volume ratio and porosity, the nanofibers created by electrospinning are able to deliver sustained drug release and oxygen to the wound. Using different types of polymers with varying properties helps strengthening nanofiber and exudates absorption. The nanofibers appear to have an ideal structure applicable for wound healing and, in combination with curcumin, can blend the anti-inflammatory and antioxidant properties of curcumin into a highly effective wound dressing. The use of suitable curcumin solvents and the slow release of curcumin from the nanofiber help in overcoming the known limitations of curcumin, specifically its low stability and limited bioavailability. Here, we review the studies which have been done on synthesized nanofibers containing curcumin, produced by the electrospinning technique, for the purpose of wound healing. |
| Keywords: | curcumin electrospinning nanofiber wound healing |