| Institution: | 1. State Key Laboratory of Oral Diseases, Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, P.R. China
Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China;2. Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu, P.R. China;3. State Key Laboratory of Oral Diseases, Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, P.R. China;4. Department of Pulmonary, Brigham and Women's Hospital, Harvard Medical School, Massachusetts;5. Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu, China;6. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, P.R. China |
| Abstract: | Bone and tooth, fundamental parts of the craniofacial skeleton, are anatomically and developmentally interconnected structures. Notably, pathological processes in these tissues underwent together and progressed in multilevels. Extracellular vesicles (EVs) are cell-released small organelles and transfer proteins and genetic information into cells and tissues. Although EVs have been identified in bone and tooth, particularly EVs have been identified in the bone formation and resorption, the concrete roles of EVs in bone and tooth development and diseases remain elusive. As such, we review the recent progress of EVs in bone and tooth to highlight the novel findings of EVs in cellular communication, tissue homeostasis, and interventions. This will enhance our comprehension on the skeletal biology and shed new light on the modulation of skeletal disorders and the potential of genetic treatment. |
