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Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis
Authors:Ben Gorissen  Alain de Bruin  Alberto Miranda-Bedate  Nicoline Korthagen  Claudia Wolschrijn  Teun J de Vries  René van Weeren  Marianna A Tryfonidou
Institution:1. Department of Pathobiology, Anatomy and Physiology Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands;2. Dutch Molecular Pathology Centre, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands;3. Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands;4. Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands;5. Department of Periodontology,, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands;6. Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

Abstract:
Keywords:cellular senescence  hypoxia  osteoclastogenesis  osteoclasts
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