miR-204-5p regulates cell proliferation,invasion, and apoptosis by targeting IL-11 in esophageal squamous cell carcinoma |
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| Authors: | Jianwei Tang Zhihua Li Quan Zhu Wei Wen Jun Wang Jing Xu Weibin Wu Yining Zhu Honglei Xu Liang Chen |
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| Institution: | 1. Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China;2. Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
Jianwei Tang and Zhihua Li contributed equally to this study. |
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| Abstract: | Esophageal cancer (EC) is the world's eighth most common malignant neoplasm and is ranked as the sixth leading cause of death related to cancer. Aberrant microRNA (miRNA) expression has been reported to be associated with esophageal squamous cell carcinoma. However, the molecular mechanism of miR-204-5p in esophageal squamous cell carcinoma (ESCC) is not clear. Therefore, the aim of this study was to investigate the potential role of miR-204-5p in ESCC. In the present study, we found that miR-204-5p could affect ESCC proliferation, invasion, apoptosis, and cell cycle in cell and mouse models. A dual-luciferase reporter assay showed that miR-204-5p expression was negatively correlated with interleukin-11 (IL-11) expression. IL-11 overexpression reversed the suppressive effects of miR-204-5p in the cell lines. These results indicated that miR-204-5p functions as a tumor suppressor by directly targeting IL-11 in ESCC. |
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| Keywords: | esophageal squamous cell carcinoma IL-11 miR-204-5p |
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