| 胎盘发生中的表观遗传学 |
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| 引用本文： | 高文龙,吉蕾,李玉侠,王雁玲.胎盘发生中的表观遗传学[J].国外医学：分子生物学分册,2010(1):59-65. |
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| 作者姓名： | 高文龙 吉蕾 李玉侠 王雁玲 |
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| 作者单位： | 中国科学院动物研究所计划生育生殖生物学国家重点实验室,北京市100101 |
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| 基金项目： | 中国科学院知识创新工程重要方向性项目（No.KSCX2-YW-R-53） |
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| 摘 要： | 胚外组织尤其是胎盘的正常发生对于维持哺乳动物胎儿在子宫中的发育和生长是必须的。胎盘发生是一个复杂的基因表达调控的过程，近年来的研究表明表观遗传在该过程中也起着重要作用。表观遗传调控在胎盘发生过程的几个主要事件中发挥作用，包括表观遗传对滋养层细胞分化和发育的调控、印记基因对胎盘发生和营养转运的调控、胎盘中的X染色体失活，以及胎盘表观遗传调控异常所导致的妊娠相关疾病。
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| 关 键 词： | 表观遗传 胎盘发生 印记基因 X染色体失活 妊娠相关疾病 |
Epigenetics in Piacentation |
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| Authors: | GAO Wenlong JI Lei LI Yuxia WANG Yanling |
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| Institution: | State (Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China) |
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| Abstract: | Normal formation of extraembryonie tissues, particularly the placenta, is necessary for growth and development of mammalian embryo. Placentation is a complex process regulated by gene expression. Accumulative data have demonstrated that epigenetics plays an important role in placenta formation. Recent studies have reported that epigenetical control mechanisms exert important functions in several major events of placentation, including trophoblast differentiation and placental development, imprinted gene expression and regulation of placental nutrient transport, imprinted X chromosome inactivation in placenta, and epigenetic factors related with gestational diseases. |
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| Keywords: | epigenetics placentation imprinted gene X-chromosomal inactivation gestational diseases |
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