FGF21对能量代谢的调控

成纤维细胞生长因子21（fibroblast growth factor 21,FGF21）作为一种不依赖胰岛素的血糖调节因子,目前已被看做是治疗2型糖尿病的一个潜在的新型治疗因素.大量鼠类及灵长类动物模型的实验结果显示：FGF21可通过作用于脂肪组织及胰腺来降低血糖和甘油三酯含量,从而预防饮食诱导的肥胖及胰岛素抵抗.此外,FGF21也被证明可作为一种主要的内源性调控子,在禁食和酮症时起着关键的调控作用.然而,一些临床观察实验的结果表明,临床观察实验与动物模型实验之间虽然具有一定的相似性,但也存在很多不同,因而目前FGF21在人体中的生理学作用仍不明确.

Regulation of Energy Metabolism by FGF21

Fibroblast growth factor 21 （ FGF21 ） is a factor regulating blood glocose independently on insulin, thus considered as a novel putative therapeutic agent for type 2 diabetes. A large amount of data, obtained from murine models and non-human primates, have showed that FGF21 can lower blood glucose and triglyceride levels via its effects on adipose tissue and pancreas, protecting against diet-induced obesity （DIO） and insulin resistance. Furthermore, FGF21 has also been proposed to play an important role in physiological response to starvation and ketosis, as a major endocrine regulator. The results from clinical observational studies and animal models studies displayed some similarities, but also differences, thus making the physiological role of FGF21 in man still unclear.